Cardiac Involvement by HIV-Associated DLBCL

Figure 1

(a–c) CT imaging of the chest without contrast. The heart is normal in size with trace pericardial effusion. Cardiac mass can be appreciated in these images. (d–j) CT abdomen and pelvis with intravenous contrast. The pancreas enlarged without focal mass. (e–j) Multiple soft tissue densities are seen in the left midkidney eroding the renal cortex. There is a mild perirenal soft tissue density rim that can be noted, more prominent in (j), left greater than right. Diffuse mesenteric edema, mild mesenteric lymphadenopathy, is also noted. (k) A high-power slide of kidney mass biopsy showing sheets of large atypical lymphocytes infiltrating the renal interstitium; scattered renal tubules are also seen (H&E, ×400). The atypical cells are immunopositive for CD45, CD20, PAX-5, and CD10, and they are negative for CD3, CD5, CD30, MUM-1, cyclin D1, BCL-2, BCL-6, CD68, and c-myc. The immunoprofile is consistent with diffuse large B-cell lymphoma (DLBCL). (l) Low-power slide of bone marrow biopsy showing bony trabeculae with diffuse infiltration of large atypical lymphocytes and dispersed marrow elements in the background (H&E, ×100). The histomorphology and immunoprofile are similar to infiltrates seen in kidney mass.

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