Herpes Simplex Virus Colitis in a Patient with Newly Diagnosed Crohn’s Disease

Figure 1

(a) Section from the ulcerated colonic mucosa with deep fissuring ulcer. Viral cytopathic changes are noted. (b, c) Giant cells within ulcer with characteristic intranuclear Cowdry type A inclusions of HSV-1 and HSV-2. Black arrows point to individual giant cells with Cowdry type A inclusions. (d) Immunohistochemistry study for HSV-2 antibody highlighted by the brown nuclear staining.

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