A Rapidly Fatal Case of Low-Dose Methotrexate Toxicity

Table 1

Studies, case series, and case reports regarding low-dose methotrexate toxicity.

Author	Year	Study type	Results
Nisar et al. [14]	1995	Retrospective study	1 patient developed pancytopenia and died
Ohosone et al. [15]	1997	Prospective study	Liver dysfunction: 3.2%; Pancytopenia: 1.4%; No fatality
Calvo-Romero et al. [12]	2001	Case series	Pancytopenia and renal impairment in both cases with 1 death
Kivity et al. [10]	2014	Retrospective study	Pancytopenia: 78.5%; Hepatic dysfunction: 28%
Jariwala et al. [16]	2014	Case series	Pancytopenia, renal dysfunction, and fatality in both cases
Mori et al. [13]	2016	Retrospective study; (only patients with myelosuppression were included)	Myelosuppression can occur abruptly at any time during therapy
Mameli et al. [17]	2017	Case report	Pancytopenia, renal dysfunction, and death