A Rare Case of New-Onset Ulcerative Colitis following Initiation of Secukinumab

Figure 2

Histological features. (a, b) Distortion of the crypt architecture, inflammation of crypts (cryptitis), frank crypt abscesses, and hemorrhage or inflammatory cells in the lamina propria. (c) Intense inflammation of the mucosa is seen. (d) The colonic mucosal epithelium demonstrates loss of goblet cells. The shape of the crypts is distorted. Also, there are features of early dysplasia towards the bottom of the crypts as seen by the deep staining and crowded nuclei.

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