Case Report
Isolated Splenic Metastases from Renal Cell Carcinoma 11 Years after Surgery
Table 1
Summary of cases of isolated splenic metastasis found in the literature.
| | Author | Age/sex | Metastasizing time | Primary (kidney) | Symptoms | Outcome | Histology type | Imaging findings | Met size |
| | Strum [4] | 59 y/M | 22 y | Right | CS | Dead (5 mo) | NS-RCC | ND | ND | | Ishida et al. [5] | 50 y/M | 7 y | Left | — | Alive (6 y) | NS-RCC | US: one solid-cystic mass with echogenic margin | 4.0 cm | | Nabi et al. [14] | 50 y/F | (synchronous) | Left | P | Alive (6 mo) | NS-RCC | CT: one solid-cystic hypoattenuating splenic mass | ND | | Kugel et al. [6] | 72 y/M | 2 y | Left | CS | Dead (1 y) | CC-RC | CT: one solid-cystic hypoattenuating splenic mass | 8.0 cm | | McGregor et al. [7] | 65 y/M | (synchronous) | Left | CS, P | ND | P-RCC | CT: one hypoattenuating, heterogeneously enhancing, splenic mass | 8.0 cm | | Shuck-Bello et al. [15] | 74 y/M | 15 y | Right | — | ND | CC-RC | CT and MRI: one hypoattenuating (CT), hypervascular splenic mass with calcifications | ND | | Ielpo et al. [9] | 82 y/M | 14 y | Left | — | Alive (1 y 3 mo) | NS-RCC | (i) CT: one solid-cystic hypovascular mass
(ii) PET/CT: no metabolic activity | 6.0 cm | | Moir et al. [10] | 70 y/F | 11 mo | Left | CS | Alive (2 y) | CC-RC | CT: one solid-cystic hypervascular splenic mass | 7.0 cm | | Nunes et al. [11] | 60 y/F | 5 y | Left | — | Alive (6 mo) | CC-RC | (i) CT and MRI: one small hypervascular splenic nodule
(ii) MRI (6 mo later): heterogeneous hypervascular mass with central necrosis | 1.0 cm–4.0 cm | | Hardikar [16] | 29 y/M | (synchronous) | Left | — | Alive (2 y) | CC-RC | CT: one hypoattenuating splenic mass | ND | | Zhang et al. [12] | 67 y/M | 2 y | Left | CS | Alive (5 mo) | NS-RCC | (i) CT w/o contrast: one isoattenuating splenic mass
(ii) PET/CT: one hypermetabolic mass | 11.4 cm | | Grewal et al. [1] | 53 y/M | 2 mo | Left | — | ND | CC-RC | PET/CT: multiple splenic lesions, one hypermetabolic | ND | | Liu et al. [13] | 75 y/M | (synchronous) | Right | CS | Alive (1 y 4 mo) | P-RCC | (i) CT: one indeterminate hypodensity
(ii) CT (9 mo later): heterogeneous splenic mass | 0.6–9.9 cm | | Romão, 2019 | 48 y/M | 11 y | Left | P | Alive (2 mo) | CC-RCC | (i) CT and MRI: two solid-cystic hypervascular masses
(ii) PET/CT: two hypermetabolic masses | 5.8 cm |
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CS: constitutional symptoms, such as weight loss and fatigue; P: pain; ND: not described; NS-RCC: nonspecified renal cell carcinoma; CC-RC: clear cell renal carcinoma; P-RCC: papillary renal cell carcinoma.
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