Case Report

Autoimmune Limbic Encephalitis in a Patient with Acute Encephalopathy and Hyponatremia

Table 1


ParameterResultReference range

Blood/serum studies
Hemoglobin12.9 g/dL11.7–16.5 g/dL
Hematocrit38.7%35.7–45.8%
WBC count10.5 k/mm34–11 k/mm3
Platelet count382 k/mm3150–460 k/mm3
Sodium127 mmol/L133–145 mmol/L
Potassium3.8 mmol/L3.8–5.2 mmol/L
Chloride88 mmol/L98–107 mmol/L
Bicarbonate27 mmol/L22–29 mmol/L
Anion gap124–17
BUN5 mg/dL6–20 mg/dL
Creatinine0.6 mg/dL0.5–1.0 mg/dL
Serum osmolality257 mOsm/kg280–290 mOsm/kg
TSH1.64 IU/L0.4–4.0 IU/L
Free T41.08 ng/dL0.7–1.8 ng/dL
AST17 U/L0–32 U/L
ALT16 U/L0–33 U/L
Alkaline phosphatase86 U/L35–104 U/L
Total bilirubin0.5 mg/dL0–1.2 mg/dL
Vitamin B12278 pg/mL232–1245 pg/mL
Calcium9.4 mg/dL8.6–10.5 mg/dL
Phosphorous3.8 mg/dL2.5–4.5 mg/dL
Magnesium1.8 mg/dL1.6–2.3 mg/dL
Glucose117 mg/dL70–99 mg/dL
Uric acid2.8 mg/dL1.6–7.6 mg/dL
Cortisol (7am)26 ug/dL6–18.4 ug/dL

Urinary studies
Urine osmolality486 mOsm/kg50–1400 mOsm/kg
Urine sodium87 mmol/L20 mmol/L
Urine barbiturate, cannabinoid, cocaine, benzodiazepine, amphetamine, opiate, oxycodoneNot detectedNot detected

Cerebrospinal fluid studies
Opening pressure21 cmH20<20 cmH20
ColorClearClear
WBC30–5
RBC10
Total protein18 mg/dL15–60 mg/dL
Glucose69 mg/dL50–80 mg/dL
Oligoclonal bands3<5
IgG index0.860.30–0.77
Meningoencephalitis PCR panelNegativeNegative
CSF gram stain and cultureNegativeNegative
CSF AFB smearNegativeNegative
CSF AFB cultureNegativeNegative
CSF fungal cultureNegativeNegative