Case Reports in Medicine / 2020 / Article / Tab 2

Case Report

Necrotizing Sarcoid Granulomatosis: A Disease Not to be Forgotten

Table 2

Characteristics of classical variant (nodular sarcoidosis) and necrotizing variant (NGS) [2, 5].

Nodular sarcoidosisNecrotizing variant

EpidemiologyPrevalence: 10 to 20 per 100,000 population
Males 44%
Females 56%
Median age: 35
<300 cases have been reported
Males 37%
Females 63%
Median age: 42
HistologyNonnecrotizing epithelioid granulomasGranulomas
Necrosis (coagulative or caseous) and vasculitis
Foci of infarction
Clinical presentation88%
Pulmonary and/or systemic symptoms (fever, weight loss, night sweats, malaise, and so on)
84%
Pulmonary and/or systemic symptons (fever, weight loss, night sweats, malaise, and so on)
Involved organs
>>SACE elevation17%4%
>>Eye involvement14%12%
>>Skin involvement10%2%
>>Lymphadenopathy9%0.5%
>>Liver involvement9%1%
>>Erithema nodosum3%1%
>>Sjögren or sicca syndrome1%3%
>>CNS involvement2%7%
>>Neuropathy0%2%
>>Splenic involvement2%1%
>>Lacrimal gland involvement1%2%
DiagnosisTransbronchial lung biopsy (35%)
Tissue obtained by surgical procedures (33%)
Needle biopsy (9%)
Bronchial biopsy (2%)
Intrathoracic lymph node biopsy (8%)
Extrathoracic lymph node biopsy (3%)
Tissue obtained by surgical procedures (98%)

SACE: serum angiotensin converting enzyme; CNS: central nervous system.