Wilson’s Disease: Diagnosis of Wilson’s Disease in Ethiopian Young Sisters

Table 1

Laboratory results of case-1 and case-2 at time of clinical evaluation at the Neurology Clinic, University of Gondar Hospital, Northwest Ethiopia.

Variable	Case-1	Case-2	Ref. value
Complete blood count
Hemoglobin (gm/dl)	15.2	8.6	12–18
WBC (×10^3/μl)	5.2	3.7	4–11
Platelets (×10^3/μl)	87.0	137	150–450
ESR (mm/hr)	1.0		0–20
Liver biochemical tests
ALT (U/L)	30.0	21	5–40
AST (U/L)	41.0	40	5–40
Alkaline phosphatase (U/L)	143.0	140	50–250
Bilirubin (total) (mg/dl)	0.80	1.24	0–3–1.5
Bilirubin (direct) (mg/dl)	0.28	0.77	0–0.3
Serum total protein (gm/dl)	7.25	6.2	6–8
Serum albumin (gm/dl)	4.10	3.6	3.5–5
Coagulation profile tests
Prothrombin time (sec)	13.5	14.6	12–14
Partial thromboplastin time (sec)	29	34	25–35
INR	1.12	1.24	0.8–1.4
Renal function tests
BUN (mg/dl)	26.0	12	15–50
Serum creatinine (mg/dl)	1.07	0.57	0.6–1.2
Thyroid function tests
Free T4 (ng/dl)	1.14	1.18	0.8–1.8
TSH (mIU/ml)	0.86	0.34	0.35–5.50
Copper studies
Serum ceruloplasmin (mg/dl)	<10.0	10.5	20–60
24 hr urinary copper (μg/24 hrs)	142.2	110.5	3.0–50.0
Serum electrolytes
Potassium (meq/L)	3.9	3.6	3.5–5.0
Sodium (meq/L)	146	140	135–145
Chloride (meq/L)	112	110	102–109
Other tests
Serum ANA	Negative	Negative
Serum RF	Negative	Negative
HBsAg	Negative	Negative
Anti-HCV antibody	Negative	Negative
Anti-HIV antibody	Negative	Negative