Posaconazole-Induced Hypertension Masquerading as Congenital Adrenal Hyperplasia in a Child with Cystic Fibrosis

Table 1

Clinical and biochemical parameters on and off posaconazole treatment.

Parameters	On posaconazole	Off posaconazole	Normal reference range
Blood pressure (mm Hg)	150/84	92/56	95/56
Urine 11-deoxycorticosterone metabolite (μg/mmol creatinine)	32	1.0	<1
Urine 11-deoxycortisol metabolite (μg/mmol creatinine)	261	11.7	<15
Plasma renin (mU/L)	2.0	N/A	15.8–100.8
Plasma aldosterone (pmol/L)	45.0	N/A	80–970
Serum cortisol on SST (nmol/L)	420	735	>500
Serum cortisone on SST (nmol/L)	41	55	19.7–77.3
Cortisol : cortisone ratio	12	3.5	1.0–10.5
17-hydroxyprogesterone on SST (nmol/L)	5	7.5	<30
Serum 11-deoxycortisol on SST (nmol/L)	102	5	<2.7
Serum 11-deoxycorticosterone on SST (nmol/L)	41	1.6	<1.4
Serum corticosterone on SST (nmol/L)	71	106	3.5–59.2
Posaconazole assay (mg/L)	6	N/A	1–3.75

Standard synacthen test; peak concentration quoted. N/A: not available.