Case Report

Posaconazole-Induced Hypertension Masquerading as Congenital Adrenal Hyperplasia in a Child with Cystic Fibrosis

Table 1

Clinical and biochemical parameters on and off posaconazole treatment.

ParametersOn posaconazoleOff posaconazoleNormal reference range

Blood pressure (mm Hg)150/8492/5695/56
Urine 11-deoxycorticosterone metabolite (μg/mmol creatinine)321.0<1
Urine 11-deoxycortisol metabolite (μg/mmol creatinine)26111.7<15
Plasma renin (mU/L)2.0N/A15.8–100.8
Plasma aldosterone (pmol/L)45.0N/A80–970
Serum cortisol on SST (nmol/L)420735>500
Serum cortisone on SST (nmol/L)415519.7–77.3
Cortisol : cortisone ratio123.51.0–10.5
17-hydroxyprogesterone on SST (nmol/L)57.5<30
Serum 11-deoxycortisol on SST (nmol/L)1025<2.7
Serum 11-deoxycorticosterone on SST (nmol/L)411.6<1.4
Serum corticosterone on SST (nmol/L)711063.5–59.2
Posaconazole assay (mg/L)6N/A1–3.75

Standard synacthen test; peak concentration quoted. N/A: not available.