Case Report

Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review

Table 2

Summary of recommended inhibitor eradication therapies found in the literature.

TherapyAuthors
Tiede et al. [16]Kruse-Jarres et al. [6]Shetty et al. [17]

CorticosteroidPrednisolone or prednisone 1 mg/kg/day orally for a maximum of 4–6 weeksPrednisone 1 mg/kg/day orally daily or dexamethasone 40 mg orally dailyPrednisone 1 mg/kg/day orally daily

RituximabDose of 375 mg/m2 for a maximum of four cyclesDose of 375 mg/m2 IV weekly for 4 weeks or dose of 100 mg weekly for 4 weeksDose of 375 mg/m2 IV weekly for 4 weeks

Cytotoxic agentsCyclophosphamide 1.5–2 mg/kg/day orally for a maximum of 6 weeks or mycophenolic acid (MMF) 1 g/day for 1 week, followed by 2 g/dayCyclophosphamide 1-2 mg/kg orally daily or cyclophosphamide ∼5 mg/kg IV for 3-4 weeksCyclophosphamide 1-2 mg/kg daily