Giant Parathyroid Adenoma-Associated Fracture, Not All Lytic Bone Lesions are Cancer: A Case-Based Review

Table 2

Patients with giant parathyroid adenoma, clinical characteristics, tumor pathologies and postoperative complications.

Case report	Gender	Age (Years)	Side	Presentation	Ca (mg/dL)/PTH (ng/L)	Dimensions (mm)	Weight (g)	Pathology	Post-operative complications
Aggarwal et al., 2009 [22]	F	33	L	Edema, palpable nodule, bone pain, R humerus and R pelvic fracture	10.6/762	95 × 50 × 35	102	Chief cell adenoma	Symptomatic hypocalcemia
Salehian et al., 2009 [23]	F	53	R	Edema, bone pain, weight loss, nausea, vomit	14.63/1624	55 × 35 × 20	30	PTA	No complication
Sisodiya et al., 2011 [24]	F	52	R	Recurrent vomit	17.03/598	39 × 20 × 17	ND	ND	Hypocalcemia
Asghar et al., 2012 [25]	F	55	L	Parathyroid crisis, palpable nodule	23.05/1182	110 × 70 × 60	ND	Cystic degeneration PTA, no lymph node metastasis	No complication
Vilallonga et al., 2012 [26]	F	19	L	Parathyroid crisis	14.23/1207	Maximum diameter 30	70	Intrathyroid PTA	No complication
Neagoe et al., 2014 [27]	M/F/F	57/60/33	R/L/R	C 1: bone pain, abdominal pain, nausea, palpable nodule. C 2: parathyroid crisis, palpable nodule. C 3: recurrent renal calculi, brown tumor in tibia	C 1 : 3.54/1780 C 2 : 16.19/863 C 3 : 12.63/1174	C 1 : 50 × 30 × 20 C 2 : 55 × 40 × 30 C3ND	C 1 : 30.6 C 2 : 35.2 C 3:>30	2 PTA; 1 partially cystic PTA	C 1: hungry bone syndrome C 2: mild hypocalcemia and hungry bone syndrome C 3: mild hypocalcemia
Haldar et al., 2014 [28]	F	61	L	Asymptomatic	12.71/179.2	65 × 30 × 15	12	PTA	No complication
Garas et al., 2015 [29]	F	53	L	Palpable nodule, bone pain	15.95/4038	Maximum diameter 70	27	Chief cell PTA	No complication
Case report	Gender	Age (Years)	Side	Presentation	Ca (mg/dL)/PTH (ng/L)	Dimensions (mm)	Weight (g)	Pathology	Post-operative complications
Rutledge et al., 2016 [30]	F	21	R	Neck mass enlargement, constipation, palpable nodule	10.94/1305.1	80 × 55 × 30	58.8	Atypical PTA	Symptomatic hypocalcemia, hungry bone syndrome
Krishnamurthy et al., 2016 [31]	M	50	L	Recurrent acute pancreatitis crisis, palpable neck mass	11.1/669	Maximum diameter 60	20	PTA	Hipocalcemia
Castro et al., 2017 [32]	F	40	L	Asymptomatic palpable nodule	13.43/825	64 × 16 × 20	10.8	PTA	Hypocalcemia
Sahsamanis et al., 2017 [33]	F	42	L	Abdominal pain	10.42/151	33 × 20 × 14	5.39	PTA	No complication
Mantzoros et al., 2018 [34]	F	73	R	Enlargement of neck size, bone pain	14.55/1629	50 × 25 × 25	30	PTA	Hungry bone syndrome
Migliore et al., 2013 [35]	F	65	R	Persistent hypercalcemia	Both elevated	―	95	PTA	No complication
Taghavi Kojidi et al., 2016 [36]	M	70	Middle	Anorexia, nausea, bone pain, constipation, symptomatic nephrolithiasis, polydipsia	14.55/930	―	75	Active parathyroid lesion	Hypocalcemia
Pecheva et al., 2016 [37]	F	72	R	Depression, severeosteoporosis (T = − 3,2)	12.1/250.8	―	19	PTA	Hoarseness, cough
Talukder et al., 2017 [38]	F	49	Middle	Brown tumor	14.07/1000	40 × 30 × 20	12	Neuroendocrine cell tumor	No complication
Garuna Murthee et al., 2018 [39]	M	72	Middle	Anorexia, lethargy, abdominal cramps, constipation, weight loss	15.19/1867.1	Maximum diameter 78	220	Intrathymic PTA	No complication
Miller et al., 2019 [40]	M	53	Middle	Asymptomatic nephrolithiasis	11.22/179.2	80 × 30 × 30	30.9	PTA	No complication
P liu et al., 2020 [41]	M	79	L/R	Obstructive right nephropathy, and acute kidney injury secondary to hypercalcemia	13.19/420.5	L: 50 × 25 × 12 R: 48 × 22 x 10	L:8101 R:7339	PTA	No complication
Giuseppe Evola et al., 2020 [42]	F	52		Musculoskeletal pain, constipation, polyuria, pathological fracture of bilateral femur	12.5/27.47	65 × 50 x 30	90	PTA	No complication
Alvarez JC et al., 2021 [our case]	F	55	R	Polyarthralgias, pathological fracture of humerus, brown tumor of humerus	14.9/1973	Maximum diameter 5	16	PTA	Hungry bone syndrome