Case Report
Two Cases of Hemophagocytic Lymphohistiocytosis Associated with Disseminated Histoplasmosis Presented with Transient Pancytopenia
Table 1
HLH-2004 diagnostic criteria.
| | The diagnosis of HLH can be established if criterion 1 or 2 is fulfilled |
| | (1) A molecular diagnosis consistent with HLH | | (2) Diagnostic criteria for HLH fulfilled (5 of the 8 below) | | Fever | | Splenomegaly | | Cytopenias (affecting ≥ 2 of 3 lineages in the peripheral blood) | | Hemoglobin < 90 g/L (hemoglobin < 100 g/L in infats < 4 weeks) | | Platelets < 100 × 109/L | | Neutrophils < 1.0 × 109/L | | Hypertriglyceridemia and/or hypofibrinogenemia | | Fasting triglycerides ≥ 3.0 mmol/L (ie, ≥265 mg/dL) | | Fibrinogen ≤ 1.5 g/L | | Hemophagocytosis in bone marrow or spleen or lymph nodes. No evidence of malignancy | | Low or no NK cell activity (according to local laboratory reference) | | Ferritin ≥ 500 μg/L | | sCD25 (ie, soluble IL-2 receptors) ≥2400 U/mL | | La Rosée et al. [10] |
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