Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Nephrology
Volume 2011, Article ID 817414, 3 pages
http://dx.doi.org/10.1155/2011/817414
Case Report

Severe Leptospirosis with Multiple Organ Failure Successfully Treated by Plasma Exchange and High-Volume Hemofiltration

1Service de Néphrologie, Département de Médecine Interne, Hôpitaux Universitaires de Genève, 1205 Genève, Switzerland
2Service des Maladies Infectieuses, Département de Médecine Interne, Hôpitaux Universitaires de Genève, 1205 Genève, Switzerland
3Service des Soins Intensifs, Département d'Anesthésiologie, de Pharmacologie et des Soins Intensifs, Hôpitaux Universitaires de Genève, 1205 Genève, Switzerland

Received 3 June 2011; Accepted 14 July 2011

Academic Editors: Y.-L. Chiu, A. L. de Francisco, C.-T. Lee, and A. Papagianni

Copyright © 2011 Vincent Bourquin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Leptospirosis is a spirochetal zoonosis with complex clinical features including renal and liver failure. Case report. We report the case of a Swiss fisherman presenting with leptospirosis. After initial improvement, refractory septic shock and severe liver and kidney failure developed. The expected mortality was estimated at 90% with clinical scores. The patient underwent plasma exchanges and high-volume hemofiltration (HVHF) with complete recovery of hepatic and kidney functions. Discussion. Plasma exchanges and HVHF may confer survival benefit on patients with severe leptospirosis, refractory septic shock, and multiple-organ failure.