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Case Reports in Nephrology
Volume 2014, Article ID 486173, 4 pages
http://dx.doi.org/10.1155/2014/486173
Case Report

Association of Acute Interstitial Nephritis with Carnivora, a Venus Flytrap Extract, in a 30-Year-Old Man with Hodgkin’s Lymphoma

University of Rochester Medical Center, 601 Elmwood Avenue, P.O. Box MED, Rochester, NY 14642, USA

Received 10 February 2014; Revised 26 March 2014; Accepted 27 March 2014; Published 15 April 2014

Academic Editor: Theodore I. Steinman

Copyright © 2014 Susan Ziolkowski and Catherine Moore. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute interstitial nephritis (AIN) is a common cause of acute kidney injury and has been associated with a variety of medications. This is the case of 30-year-old man with Hodgkin’s lymphoma who on routine labs before chemotherapy was found to have acute nonoliguric renal failure. A kidney biopsy was performed and confirmed the diagnosis of acute interstitial nephritis. The patient had taken several medications including a higher dose of Carnivora, a Venus flytrap extract, composed of numerous amino acids. The medication was discontinued and kidney function improved towards the patient’s baseline indicating that this may be the possible cause of his AIN. Proximal tubular cell uptake of amino acids increasing transcription of nuclear factor-kappaB is a proposed mechanism of AIN from this compound.