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| Patient characteristics | Dose | Duration | Laboratory values | Outcome |
|
Cicone et al. 2004 [2] | 69-year-old Caucasian female with ESRD on CAPD for 4 months. | 25 g IV 3x/week | 8 months | Average HCO3 = 15.4 mmol/L Average AG = 26.1 mmol/L | Resolution of pain and reduction in size of subcutaneous plaques. |
|
Selk and Rodby 2011 [3] | 65-year old female with ESRD on HD. | 25 g IV 3x/week after HD | Not specified | HCO3 = 10 mmol/L AG = 44 mmol/L | Acidemia prompted a significant reduction in STS dose. CUA outcome not specified. |
|
Brucculeri et al. 2005 [4] | 48-year-old Caucasian female with ESRD on HD. | 5 g IV 4x/week after HD | 34 months at time of publication. | Average HCO3 = 13.1 mmol/L Average AG = 26.7 mmol/L | Excellent wound healing without disease recurrence. |
|
Vanparys et al. 2013 [5] | 71-year-old Caucasian female status, after cadaveric renal transplant with CKD 4 secondary to cyclosporine toxicity and chronic allograft dysfunction. | 12.5 g IV BID | 2 weeks | HCO3 = 12 mmol/L AG not specified | STS dose decreased to 7.5 g BID and PO bicarbonate started. Patient showed improved wound healing but died from sepsis. |
|
Mao et al. 2013 [6] | 71-year-old Caucasian female with CKD 4. | 25 g IV daily | 2 weeks | Serum pH <6.80 HCO3 = 6 mmol/L AG = 45 mmol/L | Survived 2 cardiac arrests. Patient declined further treatment and was discharged to hospice. |
|
Rein et al. (this report) | 49-year-old Caucasian female with ESRD on CAPD. | 25 g IV daily | 5 months | HCO3 = 8 mmol/L, AG = 50 mmol/L | Dose changed to 12.5 mg IV every other day then 12.5 mg weekly. Cured of calciphylaxis in 5 months. |
51-year-old Caucasian male with ESRD started on HD. | 25 g IV 3x/week after HD | 4 months | HCO3 = 18 mmol/L, AG = 27 mmol/L | No change in STS dose. Cured of calciphylaxis in 4 months. |
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