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Case Reports in Nephrology
Volume 2015, Article ID 257628, 4 pages
http://dx.doi.org/10.1155/2015/257628
Case Report

Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease

1Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina
2Laboratory Services, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina
3IFIBIO Houssay, UBA CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1425 Buenos Aires, Argentina

Received 12 April 2015; Accepted 30 April 2015

Academic Editor: Kostas C. Siamopoulos

Copyright © 2015 H. Trimarchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The time for starting a patient with Fabry disease on enzyme replacement therapy is still a matter of debate, particularly when no overt classical clinical signs or symptoms are present. With respect to Fabry nephropathy, a dual problem coexists: the reluctance of many nephrologists to start enzyme replacement infusion until signs of renal disease appear as the appearance of proteinuria or an elevation in serum creatinine and the lack of validated biomarkers of early renal damage. In this regard, proteinuria is nowadays considered as an early and appropriate marker of kidney disease and of cardiovascular morbidity and mortality. However, in this report we demonstrate that podocyturia antedates the classical appearance of proteinuria and could be considered as an even earlier biomarker of kidney damage. Podocyturia may be a novel indication for the initiation of therapy in Fabry disease.