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Case Reports in Nephrology
Volume 2015, Article ID 635974, 4 pages
http://dx.doi.org/10.1155/2015/635974
Case Report

Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria

1Department of Internal Medicine, Ufuk University School of Medicine, 06520 Ankara, Turkey
2Division of Nephrology, Department of Internal Medicine, Ufuk University School of Medicine, 06520 Ankara, Turkey
3Department of Pathology, Hacettepe University School of Medicine, 06100 Ankara, Turkey
4Division of Hematology, Department of Internal Medicine, Ufuk University School of Medicine, 06520 Ankara, Turkey

Received 19 March 2015; Revised 12 May 2015; Accepted 13 May 2015

Academic Editor: Raoul Bergner

Copyright © 2015 Ozlem Beyler Kilic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nonsecretory multiple myeloma (NSMM) is the absence of a detectable monoclonal protein in serum and urine of a multiple myeloma (MM) patient and immunoglobulin light chain (AL) amyloidosis is a significantly rare complication. A case of NSMM with AL amyloidosis and nephrotic range proteinuria is presented. Sharing clinical, therapeutic, and prognostic characteristics with MM, real challenge may be during initial diagnosis of NSMM and assessment of treatment response. In elderly patients with unexplained renal dysfunction, MM should be in the differential diagnosis and the absence of a monoclonal protein should not rule out MM but should remind us of the possibility of NSMM.