Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Nephrology
Volume 2015 (2015), Article ID 761393, 4 pages
http://dx.doi.org/10.1155/2015/761393
Case Report

Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration

1Department of Intensive Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium
2Centre de Référence Neuromusculaire, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium
3Louvain Centre for Toxicology and Applied Pharmacology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium
4Department of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium

Received 1 December 2014; Accepted 19 March 2015

Academic Editor: Aikaterini Papagianni

Copyright © 2015 Nicolas De Schryver et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Goffin, L. Herbiet, D. Pouthier et al., “Vancomycin and ciprofloxacin: systemic antibiotic administration for peritoneal dialysis-associated peritonitis,” Peritoneal Dialysis International, vol. 24, no. 5, pp. 433–439, 2004. View at Google Scholar · View at Scopus
  2. D. P. Kofteridis, A. Valachis, K. Perakis, S. Maraki, E. Daphnis, and G. Samonis, “Peritoneal dialysis-associated peritonitis: clinical features and predictors of outcome,” International Journal of Infectious Diseases, vol. 14, no. 6, pp. e489–e493, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. X. Bosch, E. Poch, and J. M. Grau, “Rhabdomyolysis and acute kidney injury,” The New England Journal of Medicine, vol. 361, no. 1, pp. 62–72, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Zutt, A. van der Kooi, G. Linthorst, R. Wanders, and M. de Visser, “Rhabdomyolysis: review of the literature,” Neuromuscular Disorders, vol. 24, no. 8, pp. 651–659, 2014. View at Publisher · View at Google Scholar
  5. C. Baigent, A. Keech, P. M. Kearney et al., “Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins,” The Lancet, vol. 366, no. 9493, pp. 1267–1278, 2005. View at Publisher · View at Google Scholar
  6. P. D. Thompson, P. Clarkson, and R. H. Karas, “Statin-associated myopathy,” The Journal of the American Medical Association, vol. 289, no. 13, pp. 1681–1690, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Mendes, P. G. Robles, and S. Mathur, “Statin-induced rhabdomyolysis: a comprehensive review of case reports,” Physiotherapy Canada, vol. 66, no. 2, pp. 124–132, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Prueksaritanont, B. Ma, and N. Yu, “The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6,” British Journal of Clinical Pharmacology, vol. 56, no. 1, pp. 120–124, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Son, D. Lee, L. A. Lim, S. B. Jang, H. Roh, and K. Park, “Development of a pharmacokinetic interaction model for co-administration of simvastatin and amlodipine,” Drug Metabolism and Pharmacokinetics, vol. 29, no. 2, pp. 120–128, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. Y.-T. Zhou, L.-S. Yu, S. Zeng, Y.-W. Huang, H.-M. Xu, and Q. Zhou, “Pharmacokinetic drug-drug interactions between 1,4-dihydropyridine calcium channel blockers and statins: factors determining interaction strength and relevant clinical risk management,” Therapeutics and Clinical Risk Management, vol. 10, no. 1, pp. 17–26, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. C. W. Holtzman, B. S. Wiggins, and S. A. Spinler, “Role of P-glycoprotein in statin drug interactions,” Pharmacotherapy, vol. 26, no. 11, pp. 1601–1607, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. M. S. Park, H. Okochi, and L. Z. Benet, “Is ciprofloxacin a substrate of p-glycoprotein?” Archives of Drug Information, vol. 4, no. 1, pp. 1–9, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. L. C. J. Ellis, G. M. Hawksworth, and R. J. Weaver, “ATP-dependent transport of statins by human and rat MRP2/Mrp2,” Toxicology and Applied Pharmacology, vol. 269, no. 2, pp. 187–194, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. W. J. Canestaro, M. A. Austin, and K. E. Thummel, “Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review,” Genetics in Medicine, vol. 16, no. 11, pp. 810–819, 2014. View at Publisher · View at Google Scholar
  15. E. Link, S. Parish, J. Armitage et al., “SLCO1B1 variants and statin-induced myopathy—a genomewide study,” The New England Journal of Medicine, vol. 359, no. 8, pp. 789–799, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. R. D. Sawant, “Rhabdomyolysis due to an uncommon interaction of ciprofloxacin with simvastatin,” Canadian Journal of Clinical Pharmacology, vol. 16, no. 1, pp. e78–e79, 2009. View at Google Scholar · View at Scopus
  17. N. Fountoulakis, L. Khafizova, M. Logothetis, G. Fanti, and J. A. Papadakis, “Case report of rhabdomyolysis possibly associated to the interaction of ciprofloxacin with simvastatin,” Hellenic Journal of Atherosclerosis, vol. 1, no. 1, pp. 65–67, 2013. View at Google Scholar
  18. H. Y. Meltzer and P. A. Holy, “Black-white differences in serum creatine phosphokinase (CPK) activity,” Clinica Chimica Acta, vol. 54, no. 2, pp. 215–224, 1974. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Baigent, M. J. Landray, C. Reith et al., “The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial,” The Lancet, vol. 377, no. 9784, pp. 2181–2192, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Saltissi, C. Morgan, R. J. Rigby, and J. Westhuyzen, “Safety and efficacy of simvastatin in hypercholesterolemic patients undergoing chronic renal dialysis,” The American Journal of Kidney Diseases, vol. 39, no. 2, pp. 283–290, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. FDA Drug Safety Communication, New Restrictions, Contraindications, and Dose Limitations for Zocor (Simvastatin) to Reduce the Risk of Muscle Injury, US Food and Drug Administration, 2014, http://www.fda.gov/Drugs/DrugSafety/ucm256581.htm.