Granulomatosis with Polyangiitis Presenting as Pauci-Immune Crescentic Glomerulonephritis in Pregnancy

Figure 1

(a) CT scan of the chest done to investigate hemoptysis showing right upper lobe infiltrates. (b) Large cellular crescent distending Bowman’s space and compressing the glomerular tuft (arrow), interstitial chronic inflammation, and tubular epithelial reactive/regenerative changes (HE stain ×20). (c) Necrotizing lesion (fibrinoid necrosis) in the glomerular tuft (arrow) with red blood cells (HE stain ×40). (d) EM-Fibrin tactoids (long arrow), dysmorphic red blood cells (short arrow), and inflammatory cells (N) in Bowman’s space. No immune type electron dense deposits in glomerular capillary basement membrane (EM ×2900).

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