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Case Reports in Nephrology
Volume 2016, Article ID 3186714, 4 pages
Case Report

SIADH Induced by Pharyngeal Squamous Cell Carcinoma: Case Report and Literature Review

Department of Internal Medicine, University of Illinois at Chicago/Advocate Christ Medical Center, Oak Lawn, IL 60453, USA

Received 30 May 2016; Accepted 26 July 2016

Academic Editor: Phuong Chi Pham

Copyright © 2016 Hafiz Muhammad Sharjeel Arshad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is considered to be the most common cause of euvolemic hyponatremia. The most common malignancy associated with SIADH is small cell lung cancer. We present a rare case of a patient with SIADH secondary to well differentiated squamous cell carcinoma of the naso-oropharynx. Case. A 46-year-old Caucasian woman presented to emergency department with four-week history of progressive dysphagia. On examination, she was found to have a pharyngeal mass. CT scan and MRI of neck confirmed a mass highly suspicious of carcinoma. Patient’s serum sodium level decreased to 118 mEq/L and other labs including serum and urine osmolality confirmed SIADH. She was started on fluid restriction and oral sodium tablets which gradually improved her serum sodium levels. Biopsy confirmed diagnosis of squamous cell carcinoma of pharynx. Conclusion. SIADH can be caused by squamous cell carcinoma. Appropriate management includes fluid restriction.