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Case Reports in Nephrology
Volume 2016, Article ID 4162674, 4 pages
http://dx.doi.org/10.1155/2016/4162674
Case Report

Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction

1Department of Nephrology, Auckland City Hospital, Auckland 1023, New Zealand
2Department of Pathology, Auckland City Hospital, Auckland 1023, New Zealand

Received 7 January 2016; Accepted 3 February 2016

Academic Editor: John A. Sayer

Copyright © 2016 Basil Alnasrallah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy.