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Case Reports in Nephrology
Volume 2017, Article ID 3729629, 3 pages
https://doi.org/10.1155/2017/3729629
Case Report

An Intact Dopamine Sensitivity in the Brain: A Necessity to Recover Hyperprolactinemia and Galactorrhea in a Female Hemodialysis Patient?

1Department of Endocrinology, University Hospital of Antwerp, Edegem, Belgium
2Department of Nephrology, University Hospital of Antwerp, Edegem, Belgium

Correspondence should be addressed to Eva Philipse; eb.azu@espilihp.ave

Received 27 February 2017; Accepted 13 June 2017; Published 16 July 2017

Academic Editor: Władysław Sułowicz

Copyright © 2017 Eva Philipse et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A female hemodialysis patient with galactorrhea due to hyperprolactinemia was treated with different dialysis modalities to assess the effect on prolactin levels. A single session of both high-flux hemodialysis and hemodiafiltration resulted in decreased prolactin levels (16,6% and 77,2%, resp.). However, baseline prolactin levels measured immediately before the next dialysis session did not change markedly. After cabergoline treatment was started, prolactin levels normalized and galactorrhea disappeared. Thus, dopaminergic inhibition of prolactin secretion might be reduced in patients with end-stage renal disease. This dopaminergic resistance could be an important mechanism of hyperprolactinemia in hemodialysis patients and its subsequent treatment strategies.