Acute Hypocalcemia and Metabolic Alkalosis in Children on Cation-Exchange Resin Therapy

Table 1

Potassium sparing agents for management of hyperkalemia [3].

	Sodium polystyrene sulfonate (SPS)	Sodium zirconium cyclosilicate	Patiromer
FDA approval	Approved	Still pending	Approved in adults
Mechanism of action	Nonspecific sodium-cation exchange resin	Selective potassium cation binding agent	Calcium based cation exchange resin
Adverse effects	Colon necrosis, GI disturbances, hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis	GI disturbances, hypokalemia	GI disturbances, hypokalemia, hypercalcemia, hypomagnesemia