Case Reports in Nephrology / 2018 / Article / Tab 3

Case Report

Severe Symptomatic Hyponatremia Secondary to Escitalopram-Induced SIADH: A Case Report with Literature Review

Table 3

Summary of all reported cases of SIADH associated with escitalopram.

Case ReportAgeSexEscitalopram DoseOnset
(Days)
Sodium
Levels (mEq/L)
Presenting SymptomsTreatment givenResolution
(Weeks)
Comorbid conditionsMedicationsRemarks

Nashoni et al, 2004 [8]62F10 mg21110SyncopeMedication discontinuation1 weekHypertension, Hyperlipidemia
Atrial fibrillation
Protein C deficiency
Osteoporosis
Losartan
Simvastatin
Sotalol
Warfarin
Calcium
Vitamin D
Patient was later treated with Mirtazapine for depression

Nirmalani et al, 2006 [22]50M20 mg28121Weakness
Dizziness
Medication discontinuation
Fluid Restriction
5 daysDepression with Psychotic features,
Hypertension,
COPD
Osteoarthritis
GERD
Risperidone

Adiga et al, 2006 [12]81F10 mg21120Generalized weakness &
Recurrent Falls
Medication discontinuation
Hypertonic saline
1 weekAlzheimer's' disease Hypertension
Osteoporosis
Ramipril
Alendronic acid
Donepezil
Mirtazapine
HCTZ
Patient noted to have Renal tubular defect

Grover et al, 2007 [14]67F10 mg28
127DeliriumMedication discontinuation
4 weeksBipolar affective disorder
Hypertension
Diabetes mellitus
Sodium valproate
HCTZ
Gliclazide
Aspirin
Losartan
Patient was later treated with Mirtazapine & Valproate for Moderate depression

Grover et al, 2007 [14]75M10 mg10126SeizuresMedication discontinuation
2 weeksHypertension
Generalized anxiety disorder
Atenolol
Amlodipine
Patient was later treated with Mirtazapine for Generalized Anxiety disorder

Covyeou et al, 2007 [13]75FUnknown5116UnknownMedication discontinuation
5 daysHypertensionAmlodipine
HCTZ
Aspirin
Omeprazole
Alprazolam

Koski et al, 2009 [9]97F5 mg7113
Recurrent Falls & ConfusionMedication discontinuation
Fluid restriction
Hypertonic saline
UnknownHypertension, Anxiety
UTI (diagnosed 1 day prior to hospitalization)
Tolterodine
Atenolol
Furosemide
Lisinopril
Docusate
Ciprofloxacin
(started 1 day prior to hospitalization)

Tsai et al
2012 [11]
73F10 mg>60
124
122
DeliriumMedication discontinuation
Fluid restriction
2 weeks
1 week
Lewy body dementiaTrihexyphenidyl Bethanechol
Tamsulosin
Failed rechallenge of escitalopram as patient developed Hyponatremia

Pae et al, 2013 [10]47M5 mg2110SeizureMedication discontinuation
4 daysQuadriplegia with Spinal A-V Malformation
Depression
No other medication

Soysal et al, 2014 [23]76F10mg28113Confusion
Lethargy
Incontinence
Medication discontinuation
Hypertonic saline
UnknownHypertension Diabetes mellitus, Alzheimer’s disease
Sleep disorder
Losartan
Sitagliptin
Rivastigmine
Memantine
Trazodone

Diken et al, 2016 [15]59M10 mg7107Confusion, Hallucination, Drowsiness
Medication discontinuation
Fluid restriction
Hypertonic saline
4 daysCOPD
Diabetes mellitus
Aspirin, metoprolol perindopril amiodarone
Spironolactone Hydrochlorothiazide
Recent introduction of hydrochlorothiazide

Parmar et al, 2016 [20]50M10 mg394SeizureMedication discontinuation
5 daysHypertension
Panic disorder
Telmisartan
Aspirin
Developed central pontine myelinolysis from rapid correction of sodium

Rawal et al, 2017 [24]54FUnknown4116SeizureMedication discontinuation
Fluid restriction
UnknownHypertension
Depression
Telmisartan
Salt restriction

Vidyasagar et al, 2017 [25]58FUnknown14107Severe ConstipationMedication discontinuation
High salt diet
Fluid restriction
UnknownSeronegative spondyloarthropathy
Diabetes mellitus
Dysthymia
Prednisolone, Hydroxychloroquine
Methotrexate
Insulin

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