Rifampicin in Nontuberculous Mycobacterial Infections: Acute Kidney Injury with Hemoglobin Casts

Figure 2

(a) Kidney biopsy showing acute tubular necrosis (ATN) with globular cast material in the tubules and interstitial edema (hematoxylin and eosin stained 200x). (b) Special stain for hemoglobin highlights yellow staining in the globular cast material (200x). ((c) and (d)) Direct immunofluorescence staining for IgA and C3 shows granular mesangial staining, respectively (400x). (e) Ultrastructural examination shows osmophilic globular hemoglobin casts in tubular lumen (uranyl acetate and lead citrate fixation, 10,000x). (f) Ultrastructural examination shows small scattered paramesangial electron dense immune-type deposits (uranyl acetate and lead citrate fixation, 12,000x).

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