Acute Renal Failure in a Patient with Rivaroxaban-Induced Hypersensitivity Syndrome: A Case Report with a Review of the Literature and of Pharmacovigilance Registries

Table 3

Number and type of renal side effects reported for rivaroxaban (until 27 April 2019) retrieved from the VigiAccess database of the WHO Program for International Drug Monitoring (available at http://www.vigiaccess.org/).

	Rivaroxaban
First case reported	2006
Total number of side effects	121,038
Sex, n (%)
Female	54,116 (45)
Male	54,865 (45)
Age, n (%)
<65 years	23,295 (19)
≥65 years	62,105 (52)
Renal side effects, n (%)	4,323 (3.5)
Acute renal failure	2,351 (54.3)
Renal hemorrhage	363 (8.4)
Chronic kidney disease	84 (1.9)
Tubulointerstitial nephritis	24 (0.6)
Nephritic and nephrotic syndromes	16 (0.4)
End-stage renal disease	10 (0.2)

Results are presented as number of subjects (valid percentage).