Case Report
A Case of Paediatric Anti-Glomerular Basement Membrane Disease Associated with Thrombotic Thrombocytopenic Purpura
Table 1
Summary of reports of concurrent anti-GBM disease and thrombotic microangiopathy.
| | First author | Year | Cohort size | Age | Sex | Hb (g/L) | Schistocytes | Platelet count (109/L) | Biopsy confirmed TMA | ADAMTS13 | ADAMTS13 inhibitor | Treatment | Outcome |
| | Stave [11] | 1984 | 6 | | | | | | Yes | | | | | | Stallworthy [16] | 2006 | 1 | 64 | Male | 65 | Present | 42 | No | | | PEX | Spontaneous remission over 3 months | | Terryn [12] | 2007 | 1 | 37 | Male | 77 | Present | 87 | No | | | PEX Corticosteroids | Partial remission | | Gowrishankar [17] | 2009 | 1 | 38 | Male | 68 | Present | | Yes | | | PEX 9 sessions Corticosteroids | | | Torok [18] | 2010 | 1 | 43 | Male | 60 | Present | 35 | No | Low (17) | Negative | PEX Corticosteroids Cyclophosphamide | Remission after 10 weeks | | Vega-Carbrera [19] | 2013 | 1 | 27 | Male | 100 | Present | 60 | Yes | Low (<1%) | Present | PEX Corticosteroids Cyclophosphamide Rituximab Immunoglobulin | Remission within 5 weeks | | Yu [20] | 2017 | 1 | 41 | Female | 55 | Present | 28 | Yes | Normal | | PEX Corticosteroids | Remission | | Alirezaei [21] | 2018 | 1 | 25 | Male | 62 | Present | 44 | Yes | Normal | | PEX Corticosteroids Cyclophosphamide Rituximab | Remission within 1 month | | Micarelli [22] | 2020 | 1 | 71 | Female | 95 | Present | 13 | No | Low (64) | Negative | PEX Corticosteroids Cyclophosphamide | Improvement in platelet count after 5 days |
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PEX = Plasma exchange. Empty cells represent unreported data. |
