Multiple Focal Brown Tumors (Osteitis Fibrosa Cystica) in a Renal Transplant Recipient

Figure 3

Brown tumor, located at Th12. (a) H&E, x5 histologic features of a giant cell reparative granuloma, in which stromal cells are admixed with osteoclastic giant cells, bone, and areas with hemorrhage. A zonal pattern is seen. Clusters of giant cells aggregate around red blood cells. The giant cells are surrounded by a zone of reactive fibrosis which, in turn, is bounded by the reactive bone. (b) H&E, x100 stromal cells admixed with osteoclast-like giant cells. The multinucleated giant cells, indicated by green dots, aggregate around red blood cells.