Epitope Spreading: The Underlying Mechanism for Combined Membranous Lupus Nephritis and Anti-GBM Disease?

Figure 2

(a) First renal biopsy (LM): a glomerulus containing a cellular crescent (PAS, ×400). (b) First renal biopsy (LM): cellular crescent without evidence of hypercellularity (arrow) (PAMS; ×200). (c) First biopsy: deposition of granular to segmental immune complexes along the GBM (IF, IgG; ×400).

(a)

(b)

(c)