A Case of Castleman’s Disease during the Long-Term Course of Membranous Nephropathy

Table 1

Laboratory findings on admission.

Urinalysis
Specific gravity	1.019
Protein	4+
Blood	—
Sediment
Red blood cells	1–4/HPF
White blood cells	<1/HPF
Urinary biochemical tests
Daily urinary protein	6.2 g/24 h
Selectivity index	0.2
Bence-Jones protein	Negative
Complete blood count
White blood cells	5700/mL
Neutrophils	45%
Eosinophils	12%
Basophils	1%
Lymphocytes	6%
Monocytes	36%
Hemoglobin	9.8 g/dL
Platelets	23.8 × 10^4/mL
Blood biochemistry
Total protein	6.6 g/dL
Albumin	1.4 g/dL
Uric acid	5.3 mg/dL
Urea nitrogen	10.4 mg/dL
Creatinine	0.83 mg/dL
Sodium	138 mmol/L
Chloride	107 mmol/L
Potassium	4.0 mmol/L
Corrected calcium	10.1 mg/dL
Phosphate	3.5 mg/dL
Blood biochemistry (cont.)
Total bilirubin	0.2 mg/dL
Aspartate aminotransferase	27 U/L
Alanine aminotransferase	19 U/L
Lactate dehydrogenase	294 U/L
Alkaline phosphatase	170 U/L
Creatine kinase	54 U/L
Total cholesterol	125 mg/dL
LDL cholesterol	64 mg/dL
Triglycerides	102 mg/dL
Glucose	129 mg/dL
Hemoglobin A1c	5.9%
Serology
C-reactive protein	0.63 mg/dL
HBs antigen	Negative
Anti-HCV antibody	Negative
Immunoglobulin G	2894 mg/dL
Immunoglobulin A	450 mg/dL
Immunoglobulin M	253 mg/dL
Immunoglobulin G4	672 mg/dL
Complement 3 (50–98)	75 mg/dL
Complement 4 (18–49)	7 mg/dL
CH50 (23–46)	33.0 U/mL
Antinuclear antibody	<×40
Cryoglobulin	(−)
Tumor markers, infection
CEA (0.0–3.4)	3.2 ng/mL
CA19-9 (0–37)	44 U/mL
SCC (0.6–2.5)	3.5 ng/mL
Pro GRP (0–747)	50.7 pg/mL
sIL-2R (122–496)	2894 U/mL
T-SPOT	Negative

LDL, low-density lipoprotein; HBs, hepatitis B surface; HCV, hepatitis C virus; CH50, 50% hemolytic unit of complement; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; SCC, squamous cell carcinoma; GRP, gastrin releasing peptide; sIL-2R, soluble interleukin-2 receptor; T-SPOT, T cell spot test for tuberculosis; HPF, high-power field.