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Case Reports in Neurological Medicine
Volume 2013 (2013), Article ID 141983, 6 pages
http://dx.doi.org/10.1155/2013/141983
Case Report

Positron Emission Tomography—Computer Tomography Scan Used as a Monitoring Tool Following Cellular Therapy in Cerebral Palsy and Mental Retardation—A Case Report

1Department of Medical Services and Clinical Research, NeuroGen, Brain and Spine institute Private limited, Surana Sethia—Hospital and Research Centre, Suman Nagar, SionTrombay Road, Chembur, Mumbai 400071, Maharashtra, India
2Department of Research and Development, NeuroGen, Brain and Spine institute Private limited, Surana Sethia—Hospital and Research Centre, Suman Nagar, SionTrombay Road, Chembur, Mumbai 400071, Maharashtra, India
3Department of Neuro-Rehabilitation, NeuroGen, Brain and Spine institute Private limited, Surana Sethia—Hospital and Research Centre, Suman Nagar, SionTrombay Road, Chembur, Mumbai 400071, Maharashtra, India
4Consultant Neuropathologist, Department of Medical Services and Clinical Research, NeuroGen, Brain and Spine institute Private limited Surana Sethia—Hospital and Research Centre Suman Nagar, SionTrombay Road, Chembur Mumbai 400071, Maharashtra, India

Received 31 October 2012; Accepted 6 December 2012

Academic Editors: H. Ikeda, Y. Iwasaki, and J.-H. Park

Copyright © 2013 Alok Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cerebral palsy (CP) is one of the non-progressive neurological diseases caused by damage to the brain tissue at birth, which leads to physical, cognitive and perceptive symptoms. Even after lifelong medical and therapeutic management there are residual deficits which affect the quality of life of the patients and their families. We examined a maximally rehabilitated, 20 year old male suffering from CP and Mental Retardation (MR). He had diplegic gait and Intelligence Quotient (IQ) score of 44 with affected fine motor activities, balance, speech and higher functions. Positron Emission Tomography—Computer Tomography (PET-CT) scan identified frontal, temporal, parietal, occipital, left cerebellar lobes, amygdala, hippocampus, and parahippocampus as the affected areas. He was treated with cellular therapy of Autologous Bone Marrow Derived Mono-Nuclear Cells (MNCs) transplantation followed by multidisciplinary rehabilitation. Six months following therapy, PET-CT scan showed significant increase in metabolic activity in all four lobes, mesial temporal structures and left cerebellar hemisphere, also supported by clinical improvement in IQ, social behavior, speech, balance and daily functioning. These findings provide preliminary evidence to support the efficacy of cellular therapy for the treatment of CP with MR. PET-CT scan can also be viewed as an impressive tool to monitor the effects of cellular therapy.