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Case Reports in Neurological Medicine
Volume 2013, Article ID 356526, 5 pages
Case Report

De Novo Glioblastoma in the Territory of a Prior Middle Cerebral Artery Infarct

1Department of Neurological Surgery, College of Physicians and Surgeons, Neurological Institute of New York, Columbia University, 710 W 168th Street, New York, NY 10032, USA
2Department of Pathology, Columbia University, College of Physicians and Surgeons, 1130 St. Nicholas Avenue, New York, NY 10032, USA

Received 22 July 2013; Accepted 11 September 2013

Academic Editors: D. B. Fee, H. Ikeda, and M. Swash

Copyright © 2013 Teresa J. Wojtasiewicz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a case of a patient who developed glioblastoma in the territory of a previous infarction. Two years after an ischemic stroke, the patient presented with a cystic, necrotic, and heterogeneously enhancing mass. Open biopsy and debulking of the mass with histological analysis revealed the mass to be glioblastoma. Though several cases of posttraumatic GBM have been reported, this is the first proposed case of GBM after an ischemic stroke. From this case, we suggest that the ischemic stroke, like other forms of cortical injury, may predispose to glioblastoma formation.