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Case Reports in Neurological Medicine
Volume 2013, Article ID 895057, 2 pages
Case Report

Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations

1Division of Pediatric Neurology, Department of Pediatrics, Scott & White Healthcare/Texas A&M, Health Science Center College of Medicine, 2401 S. 31st Street, Temple, TX 76508, USA
2Texas A&M Health Science Center College of Medicine, Temple, TX 76508, USA
3Epilepsy Center, Department of Neurology, Scott & White Neuroscience Institute/Texas A&M, Health Science Center College of Medicine, Temple, TX 76508, USA

Received 14 November 2013; Accepted 4 December 2013

Academic Editors: D. B. Fee and R. Hashimoto

Copyright © 2013 Jose Aceves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Hemiplegic migraine is a rare type of migraine that may present in children and adolescents. Both familial and sporadic hemiplegic migraines have similar prevalence and clinical characteristics. Patient. We report an adolescent with sporadic hemiplegic migraine who previously had a similar attack in the past and who was initially evaluated for a possible acute ischemic event. Results. Magnetic resonance angiography showed dilatation of the left middle cerebral artery that resolved in a follow-up study. She was also found to have a ATP1A2 (c.2273 G>C) mutation and a heterozygous prothrombin mutation. Conclusions. We suggest that patients with sporadic hemiplegic migraine be tested for both ATP1A2 mutations which in some cases may be pathogenic, and prothrombin mutations which increase the stroke risk for this patient population.