Understanding Cerebellar Liponeurocytomas: Case Report and Literature Review

Table 1

Review of cases of cerebellar liponeurocytoma (including ours).

Author/year	Designation	Age/sex	Location	Treatment/adjuvant therapy	Proliferation; index	Follow-up	Recurrence
Bechtel et al. 1978 [7]	Mixed mesenchymal and neuroectodermal tumor	44/M	LCH	Surgery	—	Died postop	—
Chimelli et al. 1991 [30]	Lipomatous differentiation in MDB	42/M	LCH	Surgery (GTR)	—	5 years 4 months	None
Davis et al. 1993 [9]	Lipidized MDB	49/F	Vermis	Surgery (STR)	—	5 years	None
		53/M	Vermis with bilateral extension	Surgery (GTR)/RT	—	Died at 6 months	—
Ellison et al. 1993 [8]	Neurolipocytoma	50/F	RCH	Surgery	<1%	4 years	None
Soylemezoglu et al. 1996 [17]	Lipomatous MDB	48/F	RCH	Surgery (STR)/RT	<1%	3.5 years	None
		59/F	LCH and CPA	Surgery (GTR)/RT	<3%	5 years	None
Giangaspero et al. 1996 [6]	Lipidized MDB	36/M	LCH	Surgery	<1%	15 years	1st R at 10 years, 2nd 5 years later (reoperation on each)
		37/M	LCH	Surgery	<1%	11 years	1st R at 10 years, 2nd one year later; died postop of ICH
		57/F	Vermis	Surgery/RT	<1%	2 years	None
Orlandi et al. 1997 [31]	Lipomatous MDB	55/M	Vermis and LCH	Surgery (GTR)	<1%	8 months	None
Alleyne et al. 1998 [10]	Lipomatous glioneurocytoma	66/M	RCH and CPA	Surgery (GTR)/RT	3.5%	—	—
Alkadhi et al. 2001 [18]	Cerebellar LNC	38/M	Vermis and RCH	Surgery (GTR)	Low	15 months	None
		53/M	LCH and CPA and C1 space	Surgery (GTR)	<5%	16 years	1st R at 12 years, 2nd 4 years later (reoperation on each)
Jackson et al. 2001 [1]	Cerebellar LNC	66/M	LCH with hemorrhage	Surgery (GTR)/RT	3%	6 months	—
Taddei et al. 2001 [26]; Cacciola et al. 2002 [27]; Buccoliero et al. 2005 [28]; Pasquale et al. 2009 [3]	Cerebellar LNC	61/M	RCH	Surgery (GTR)	15% focally at onset; 20% at relapse	8 years	R at 3.5 years (surgery + IORT)
Montagna et al. 2002 [32]	Cerebellar LNC	53/F	RCH	Surgery (STR)/RT	<5%	4 years	None
Akhaddar et al. 2003 [33]	Cerebellar LNC	43/F	LCH	Surgery (GTR)/RT	<2%	16 months	None
El Shihabi et al. 2003 [34]	Lipomatous MDB	45/F	Multicentric: RCH, CPA, and LCH	Surgery (STR)/RT/CMT	<2.5%	3 years	None
Kachhara et al. 2003 [21]	LNC of the cerebellum	62/F	RCH and C1-2 space	Surgery (GTR)	—	—	—
Amina et al. 2003 [35]	Cerebellar LNC	38/F	LCH	Surgery	—	—	—
Jenkinson et al. 2003 [2]	Cerebellar LNC	51/F	RCH	Surgery (STR)/RT	<3%	15 months	1st R at 12 months, 2nd 3 months later (reoperation on each)
Valéry et al. 2004 [36]	Cerebellar LNC	74/F	RCH	Surgery (GTR)/RT	5%	12 months	None
Aker et al. 2005 [23]	Cerebellar LNC	49/F	Vermis and 4th vt	Surgery (STR)/RT	<1%	Died at 19 months	None
Bazarbacha et al. 2005 [37]	Cerebellar LNC	38/F	Cerebellar	Surgery	—	—	—
Tatke and Singh 2005 [38]	Cerebellar LNC	32/F	Cerebellar	Surgery	—	—	—
Patel et al. 2009 [39]	Cerebellar LNC	40/F	RCH and CPA	Surgery (GTR)	—	3 years	None
Limaiem et al. 2009 [20]	Cerebellar LNC	42/M	RCH and vermis	Surgery (GTR)	2% at onset; <3% at recurrence	11 years	R at 10 years: reoperation
Châtillon et al. 2009 [40]	Cerebellar LNC	42/F	RCH	Surgery (GTR)/RT	5 to 10%	3 years	None
Chakraborti et al. 2011 [14]	Cerebellar LNC	45/F	Midline	Surgery (GTR)	<1%	—	—
Anghileri et al. 2012 [19]	Cerebellar LNC	40/F	Vermis	Surgery (GTR)	1-2%	11 years	R at 8 years (no action)/spinal metastasis at 11 years: resection
		59/F	Vermis	Surgery (STR)	1-2%	10 years	R at 15 months: reoperation and radiosurgery
Guan et al. 2012 [22]	Cerebellar LNC	50/M	Cerebellar	Surgery	—	—	—
Chung et al. 2012 [29]	Cerebellar LNC	49/M	Vermis and 4th vt	Surgery (GTR)/RT	13.6%	12 months	—
Beizig et al. 2013 [41]	Cerebellar LNC	45/F	Vermis	Surgery (GTR)	—	18 months	None
Dey et al. 2013 [42]	Cerebellar LNC	30/F	LCH	Surgery (STR)	3%	6 months	—
Present case 2013	Cerebellar LNC	64/F	RCH and CPA	Surgery (STR)	<1%	2 years	None

LNC: liponeurocytoma; MDB: medulloblastoma; RCH: right cerebellar hemisphere; LCH: left cerebellar hemisphere; CPA: cerebellopontine angle; GTR: gross total removal; STR: subtotal removal; RT: radiotherapy; R: recurrence; ICH: intracerebral hemorrhage; IORT: intraoperative radiotherapy.