Intermittent Atrioventricular Block following Fingolimod Initiation
Figure 1
(a) Magnetic resonance imaging of the brain and spinal cord at relapse. (A) Sagittal T2-weighted image showing lesions in the corpus callosum. (B) Axial FLAIR image showing hyperintense lesions in the periventricular white matter of both hemispheres. (C) Axial T1-weighted image showing a gadolinium-enhancing lesion in the right upper and middle cerebellar peduncle. (D) Sagittal T1-weighted image showing a gadolinium-enhancing lesion on thoracic spinal cord at T1-T2 level. ((F) and (E)) Axial T2- and T1-weighted images of the spinal cord showing the extent of the T1-T2 lesion in the axial plane and that of gadolinium enhancement, respectively. (b) ECG Holter strip that shows Weckenbach type 2nd degree AV block 5 hours after initial dose of fingolimod.
