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Case Reports in Neurological Medicine
Volume 2016, Article ID 1978461, 4 pages
http://dx.doi.org/10.1155/2016/1978461
Case Report

Aseptic Meningitis Caused by Lassa Virus: Case Series Report

1Department of Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria
2Institute of Lassa fever Research and Control, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria
3Lassa Fever Ward, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria
4Department of Paediatrics, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria

Received 10 July 2016; Accepted 13 October 2016

Academic Editor: Chin-Chang Huang

Copyright © 2016 Peter O. Okokhere et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Lassa virus is known to cause disease in different organ systems of the human body, with varying clinical manifestations. The features of severe clinical disease may include bleeding and/or central nervous system manifestations. Whereas Lassa fever encephalopathy and encephalitis are well described in the literature, there is paucity of data on Lassa virus meningitis. We present the clinical description, laboratory diagnosis, and management of 4 consecutive cases of aseptic meningitis associated with Lassa virus infection without bleeding seen in a region of Nigeria known to be endemic for both the reservoir rodent and Lassa fever. The 4 patients recovered fully following intravenous ribavirin treatment and suffered no neurologic complications.