Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Neurological Medicine
Volume 2016 (2016), Article ID 3502683, 6 pages
http://dx.doi.org/10.1155/2016/3502683
Case Report

Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature

1King Abdulaziz Medical City/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia
2King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia
3King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, P.O. Box 12723, Jeddah 21483, Saudi Arabia

Received 23 March 2016; Accepted 12 April 2016

Academic Editor: Isabella Laura Simone

Copyright © 2016 Hussein Algahtani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first discovered in September 2012 in Saudi Arabia. Since then, it caused more than 1600 laboratory-confirmed cases and more than 580 deaths among them. The clinical course of the disease ranges from asymptomatic infection to severe lower respiratory tract illness with multiorgan involvement and death. The disease can cause pulmonary, renal, hematological, and gastrointestinal complications. In this paper, we report neurological complications of MERS-CoV in two adult patients, and we hypothesize the pathophysiology. The first patient had an intracerebral hemorrhage as a result of thrombocytopenia, disseminated intravascular coagulation, and platelet dysfunction. The second case was a case of critical illness polyneuropathy complicating a long ICU stay. In these cases, the neurological complications were secondary to systemic complications and long ICU stay. Autopsy studies are needed to further understand the pathological mechanism.