A 66-Year-Old Woman with a Progressive, Longitudinally Extensive, Tract Specific, Myelopathy

Figure 4

Spinal cord stained immunohistochemically with antibody to neurofilament (NF) demonstrates regional axonal loss; (a) low-power photomicrograph demonstrates areas of axonal loss most pronounced in the dorsal (upper boxed area) and lateral white matter tracts, in contrast to ventral spinal cord (lower boxed area) (original magnification, ×20; NF immunostain); (b, c) higher-power photomicrographs of boxed areas to demonstrate axonal loss in dorsal columns ((b) upper boxed area from (a)) with relative axonal preservation in ventral area ((c) lower boxed area from (a)) (original magnifications, ×200; NF immunostain).

(a)

(b)

(c)