Methylprednisolone slow-release, cortivazol (3.75 mg in 1.5 mL saline), plus lidocaine
Dihydroergotamine
C
Alternative
1 mg sc/im
Prophylactic treatment
Verapamil
B
First line
360 mg/day (240–960)
Lithium
C
First line
900 mg/day (600–1200)
Valproic acid
C
Second line
500–2000 mg/day
Topiramate
B
Second line
50–200 mg/day
Baclofen
C
Second line
15–30 mg/day
Melatonin
C
Alternative
10 mg/day
sc: subcutaneous; im: intramuscular; level of evidence: A, data derived from multiple randomized clinical trials or meta-analyses; B, data derived from a single randomized clinical trial or large nonrandomized studies; C, consensus of opinion of the experts and/or small studies, retrospective studies, and registries.