Case Report

Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome

Table 2

Main characteristics of the patients with concurrent acute/subacute autoimmune neuromuscular disorders diagnosed at the same time (ranked in descending chronological order).

ReferencesType of NMDAgeSexDescription of NMD
NMMG

Our observations [2]
 Patient 167FSimultaneous diagnosis of MG (no thymus abnormality), subacute inflammatory neuropathy, and myositis
 Patient 279MSimultaneous diagnosis of MG (no thymus abnormality), subacute inflammatory neuropathy, and myositis
Tanaka & Satomi, 2016 [3]69FSimultaneous diagnosis of MFS (positivity of anti-GQ1b antibodies) and MG
Seton et al., 2013 [4]46FSimultaneous diagnosis of PM and MG (with thymoma)
Paik et al., 2014 [5]
 Patient 175FSimultaneous diagnosis of DM and MG
 Patient 244MSimultaneous diagnosis of PM and MG (with thymic mass and lymphoid follicular hyperplasia)
 Patient 354MSimultaneous diagnosis of PM and MG
 Patient 438FSimultaneous diagnosis of DM and MG (with thymic mass and lymphoid follicular hyperplasia)
 Patient 561MSimultaneous diagnosis of PM and MG
 Patient 624FSimultaneous diagnosis of PM and MG
Belin et al., 2013 [6]58MSimultaneous diagnosis of GBS and MG
Reimann et al., 2011 [7]57MSimultaneous diagnosis of myositis and neuropathy with pipestem capillaries and vascular activated complement deposition
Hill et al., 2011 [8]67FSimultaneous diagnosis of DM and MG
Kung et al., 2009 [9]36FSimultaneous diagnosis of GBS and MG
Nomura et al., 2010 [10]52FSimultaneous diagnosis of DM and severe axonal neuropathy (nerve biopsy: axonal atrophy, ovoids, no demyelinating feature, no vasculitis)
Kizilay et al., 2008 [11]52MSimultaneous diagnosis of GBS and MG
Kraus et al., 2007 [12]65MDevelopment of MG 10 weeks after GBS
Yoshidome et al., 2007 [13]62FSimultaneous diagnosis of PM and MG
Avni et al., 2006 [14]66MMG (with thymoma) diagnosed 2 weeks after treatment for PM (with high level of blood eosinophils)
Shichijo et al., 2005 [15]57MSimultaneous diagnosis of DM and MG
Farah et al., 2005 [16]71FDiagnosis of AMSAN two years after a diagnosis of MG
Diaco et al., 2004 [17]47FMyositis (antisynthetase syndrome) developed in a context of MG
Matsui et al., 2003 [18]
 Case  168FSimultaneous diagnosis of DM and inflammatory neuropathy
 Case  248FSimultaneous diagnosis of DM and inflammatory neuropathy
Van de Warrenburg et al., 2002 [19]28FSimultaneous diagnosis of DM and MG
Otton et al., 2000 [20]71MSimultaneous diagnosis of MG (with thymoma) sensorimotor neuropathy (no nerve biopsy), and PM
Kornizky et al., 2000 [21]69MPM in a context of MG
Raschilas et al., 1999 [22]66FSimultaneous diagnosis of PM and MG (with malignant thymoma)
Kobayashi et al., 1997 [23]14FPM developed 29 years after MG (in a context of Grave’s syndrome)
Ko et al., 1995 [24]25FSimultaneous diagnosis of PM and MG (with thymoma), with also autoimmune active chronic hepatitis
Vogelgesang et al., 1995 [25]9MSimultaneous DM and sensorimotor neuropathy (no biopsy)
7FSimultaneous DM and sensorimotor neuropathy (nerve biopsy: vasculitis)
Hausmanowa-Petrusewicz et al., 1995 [26]58FDM developed 9 years after MG
Hassel et al., 1992 [27]37MSimultaneous diagnosis of PM and MG two days after thymectomy (for thymoma)
Carlander et al., 1991 [28]45MMG with recurrent episodes of GBS
García-Merino et al., 1991 [29]68MInflammatory neuropathy (and continuous muscle fiber activity) developed 12 years after a diagnosis of MG (with thymoma)
Behan et al., 1982 [30]56MSimultaneous diagnosis of PM and MG, with also Hashimoto’s thyroiditis, pemphigoid, carcinoma of the bladder, and Norwegian scabies
Boudouresques et al., 1981 [31]MG developed 7 months prior to GBS
Davis & Gallai, 1979 [32]71FMG developed after PM
Vasilescu et al., 1978 [33]
 Case  124FSimultaneous diagnosis of DM and MG
 Case  246MSimultaneous diagnosis of DM and MG
 Case  318FSimultaneous diagnosis of DM and MG
 Case  442FSimultaneous diagnosis of DM and MG
De Reuck et al., 1976 [34]23MSimultaneous diagnosis of PM and MG

AMSAN: acute motor sensory axonal neuropathy; DM: = dermatomyositis; GBS: Guillain-Barré syndrome; M: myositis; MFS: Miller Fisher syndrome; MG: myasthenia gravis; N: acute/subacute neuropathy; NMD: neuromuscular disorder; PM: polymyositis.