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Case Reports in Neurological Medicine
Volume 2017, Article ID 5146723, 3 pages
https://doi.org/10.1155/2017/5146723
Case Report

Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review

1Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
2Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI, USA

Correspondence should be addressed to Abhimanyu Mahajan; gro.shfh@1ajahama

Received 28 December 2016; Accepted 19 March 2017; Published 23 March 2017

Academic Editor: Norman S. Litofsky

Copyright © 2017 Tarun Girotra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hemochromatosis is an autosomal recessive disorder which leads to abnormal iron deposition in the parenchyma of multiple organs causing tissue damage. Accumulation of iron in the brain has been postulated to be associated with several neurodegenerative diseases including Parkinson’s disease. The excess iron promotes Parkin and α-synuclein aggregation in the neurons. Excess iron has also been noted in substantia nigra on MRI especially using susceptibility weighted imaging in patients with Parkinson’s disease. We present a case of a young male with alleles for both C282Y and H63D who presented with signs of Parkinsonism and demonstrated significant improvement with levodopa treatment.