Rheumatoid Meningitis Occurring during Etanercept Treatment

Table 1

Cases of rheumatoid meningitis during treatment with a TNF-α blocker.

Case (age, sex)	Symptoms	TNF-α inhibitor	Duration from administration of TNF-α inhibitor to the onset of rheumatoid meningitis	Treatment
58F [9]	Headache, psychomotor retardation, focal seizures	Adalimumab	7 months	Discontinuation of adalimumab; Steroid; Rituximab
77M [5]	Headache, expressive dysphasia, involuntary movements of upper extremities, confusion	Adalimumab	2 weeks	Discontinuation of adalimumab; Steroid
58F [6]	Headache, emotional lability, left facial numbness, slurred speech, weakness and numbness of the extremities, frequent falls, seizures	Infliximab	3 months	Discontinuation of infliximab; Steroid; Cyclophosphamide
64M [10]	Aphasia, convulsion, focal seizure of the right side of the body	Infliximab	7 months	Discontinuation of infliximab; Steroid
65M (present case)	Seizure	Etanercept	6 months	Discontinuation of etanercept; Steroid