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Case Reports in Neurological Medicine
Volume 2018, Article ID 2314791, 3 pages
Case Report

Levodopa-Responsive Early-Onset Parkinsonism in Down Syndrome

Children’s Hospital Colorado, 13123 E. 16th Ave., Aurora, CO 80045, USA

Correspondence should be addressed to Padmini Palat; gro.odarolocsnerdlihc@talap.inimdap

Received 30 October 2017; Accepted 23 January 2018; Published 15 February 2018

Academic Editor: Peter Berlit

Copyright © 2018 Padmini Palat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Individuals with Down syndrome (DS) can develop Alzheimer’s disease as early as 30 to 40 years old, but parkinsonism is rarely described. We report on a 20-year-old woman with Down syndrome and parkinsonism who responded dramatically to carbidopa-levodopa. We propose that the occurrence of parkinsonism in individuals with DS may be underreported. Recognizing and treating this condition may improve quality of life.