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Case Reports in Neurological Medicine
Volume 2018, Article ID 5872638, 4 pages
Case Report

Corticobasal Syndrome Associated with Antiphospholipid Syndrome Secondary to Systemic Lupus Erythematosus

Department of Neurology, International University of Health and Welfare Hospital, Tochigi, Japan

Correspondence should be addressed to Ritsuo Hashimoto;

Received 2 February 2018; Accepted 25 March 2018; Published 7 May 2018

Academic Editor: Tapas Kumar Banerjee

Copyright © 2018 Ritsuo Hashimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report the case of a 53-year-old woman diagnosed with corticobasal syndrome (CBS) due to antiphospholipid syndrome (APS) secondary to systemic lupus erythematosus. Brain MRI showed marked cortical atrophy, several small infarctions in the deep white matter, and mild white matter changes, all of which were probably due to thrombosis manifestations of APS and could also be related to the CBS. To the best of our knowledge, this is the fourth reported case of CBS due to APS. It is noteworthy that although the common underlying pathologies of the CBS are neurodegenerative diseases, either primary or secondary APS can manifest itself as the CBS.