Oral Perampanel for the Treatment of Super-Refractory Status Epilepticus

Table 1

Chronology of the introduction of antiepileptic drugs and their correspondent doses. Those drugs without significant effect on seizures control were progressively stopped.

Time from seizures beginning.	Valproic acid	Midazolam	Thiopental	Levetiracetam	Lacosamide	Perampanel
5 Minutes	40 mg/kg loading dose followed by 500 mg intravenously every 6 hours
20 Minutes		0.2 mg/kg loading dose titrated to 1.5 mg/kg/hour intravenously		1.5 g every 12 hours per nasogastric tube
60 Minutes			3 g/24 hours intravenously till burst suppression on EEG.
3 Hours					200 mg intravenously every 12 hours
24 Hours						4 mg per nasogastric tube
36 Hours						4 mg per nasogastric tube
48 Hours		Tapering till stopped	Tapering till stopped			8 mg per day
72 Hours and beyond	Tapering till stopped			Tapering till stopped	Tapering till stopped	Maintenance dose of 8 mg per day