Unusual Phenotype and Disease Trajectory in Kearns–Sayre Syndrome
Table 1
Disease trajectory of the presented patient over 49 years of age.
Onset (age)
Manifestation
Therapy
Intrauterine
Premature birth (7 weeks earlier)
None
Birth
Congenital anisocoria
None
Infancy
Developmental delay
None
Infancy
Hypoacusis
Hearing devices since age 39
Childhood
Downslowing, chronic fatigue
None
Childhood
Sicca syndrome + recurrent conjunctivitis
Eye drops
Childhood
Recurrent respiratory infections
Antibiotics
Childhood
Recurrent herpetic infections, stomatitis
Virostatics
5 y
Painless desquamation of hands and feet
None
6 y
Ophthalmoparesis (first recognised)
None
7 y
Tetra-ataxia
None
18 y
Severe caries
Full prosthesis
27 y
Right-sided inguinal hernia
Bassini surgery
29 y
Sacral dermoidal cyst
Surgery
30 y
Bifascicular block
None
30 y
Erythema nodosa of feet
Steroids
35 y
Hyper-CKemia
None
35 y
Hyperuricemia
Diet
35 y
Hyponatremia, hypokalemia
NaCl, KCl
36 y
Somnolence, infection, suspected BE, SLE
Antibiotics, virostatics, endobolin, steroids
36 y
Suspected SLE
None
36 y
Elevated CSF protein
None
36 y
Dysarthria
None
36 y
Polyposis of nasal sinuses
None
36 y
Gait disturbance, falls
None
36 y
Neuropsychological deficits
Training
37 y
Arterial hypertension
Antihypertensives
37 y
Hepatopathy
None
37 y
Liver cysts
None
37 y
Rhabdomyolysis (CK: 2673 U/L)
None
38 y
Chondroma/fibroma of the right femur
None
38 y
Steatosis hepatis
None
44 y
Suspected SLE, Na↓, K↓, migraine
Analgesics
45 y
Fall, rib fracture, pneumothorax
Drainage
45 y
Diabetes
Antidiabetics
47 y
Cataract bilaterally
Surgery
49 y
Aortic ectasia
None
Left anterior hemiblock plus right bundle branch block, SLE: stroke-like episode, nr: not relevant, CSF: cerebrospinal fluid, BE: Bickerstaff encephalitis.