Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor?

Figure 1

(a) Axial fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted magnetic resonance imaging (DWI) upon symptom presentation showed diffuse symmetric deep white matter involvement of the centrum semiovale posterior frontal and parietal, with T2/FLAIR hyperintensity and restricted diffusion (first row of images), which extend continuously to the splenium of the corpus callosum (second row of images). (b) Follow-up MRI 1 month after presentation showed significant symmetric improvement of the findings on FLAIR and DWI images. The FLAIR abnormalities had improved both in volume and intensity; subtle increased signal could still be traced on DWI images, with no actual restricted diffusion on ADC map images.

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