Cutaneous hyperpigmentation (maculopapular rash)
Jaundice
Vitiligo
Pallor | Gastrointestinal glossitis (pain, swelling, tenderness, and loss of papillae) | Hematologic
Anemia (macrocytic, megaloblastic) L
eukopenia P
ancytopenia (bone marrow suppression) thrombocytosis
Elevated indirect bilirubin
Elevated AST
Decreased haptoglobin level
Elevated MMA
Elevated homocysteine
Elevated LDH
Thrombocytopenia | Neuropsychiatric
Areflexia, Forgetfulness,
Restless leg syndrome,
Ataxia or positive R
homberg test
Extrapyramidal signs (eg, dystonia, dysarthria, and rigidity),
Cognitive impairment (including dementia-like
Cognitive slowing and acute psychosis),
Gait abnormalities
Depression or changes in mood, Irritability
Lhermitte sign,
Peripheral sensory deficits (loss of proprioception and vibratory sense)
Olfactory impairment,
Peripheral neuropathy
Optic atrophy
Anosmia
Loss of taste |
