Clear Cell Carcinoma of the Endometrium Causing Paraneoplastic Retinopathy: Case Report and Review of the Literature

Table 1

Reported gynecologic cancers associated with paraneoplastic retinopathy.

Reference	Age at diagnosis	Origin of cancer	Interval between diagnosis of primary tumor and onset of visual symptoms (months)	Interval from visual symptoms to death (months)
[2]	62	Endometrioid sarcoma	+5	7
[3]	77	Poorly differentiated adenocarcinoma of the ovary	−23	23
[4]	60	Papillary cystadenocarcinoma of ovary	+7	NA
[5]	50	Uterine cancer	+36	No information
[6]	89	Poorly differentiated carcinoma of ovary	−15	15
[7]	61	Undifferentiated neoplasm of the cervix uteri	−7	20
[8]	64	Undifferentiated endometrial adenocarcinoma	Initial diagnosis: +8; recurrence: −3	3
[9]	68	Carcinoma of the cervix	−3	12
	65	Serous cystadenocarcinoma of ovary	+24	Well after 78 months
[10]	63	Clear cell carcinoma of ovary	−5	8
[11]	72	Uterine small cell carcinoma	−2	6
[12]	65	Malignant mixed mullerian tumor (homologous) of the endometrium	−1	NA
[13]	77	Anaplastic uterine carcinoma	+10	NA
[14]	60	Endometrial carcinoma	Initial diagnosis: −3; recurrence: −11	27
[15]	67	Small-cell endometrial carcinoma	+12	4
[16]	35	Carcinoid tumour of cervix	Article in german
[17]	60	Mixed-type small cell carcinoma of endometrium	Initial diagnosis: −4; recurrence: −18	30
[18]	55	Clear cell carcinoma of ovary	+27	4
[19]	75	Poorly differentiated adenocarcinoma of the ovary	−11	Not stated; patient died after 6 courses of chemotherapy
[1]	77	Adenocarcinoma cervix	−0.5 –1	NA
[20]	35	Serous ovarian cancer and endometrial carcinoma	Initial diagnosis: +24; recurrence: +1	6
[21]	70	Uterine cancer	+12	54
[22]	58	Small cell undifferentiated carcinoma with minor components of endometroid and mucinous grade 1/3 of the endometrium	−1	2
[23]	57	Uterine small cell carcinoma	−1.5	NA
[24]	66	Endometrial carcinoma	+4	NA
[25]	67	Endometrial carcinoma	Concomitant	NA
[26]	68	Adenocarcinoma of cervix	−48	NA
[27]	70	Neuroendocrine carcinoma of fallopian tube	−22	NA
Current	62	Clear cell carcinoma of the uterus	+8	NA

The interval between diagnosis of the inciting tumor and the diagnosis of retinopathy is listed as positive numbers if the inciting tumor was diagnosed before the diagnosis of retinopathy and as negative numbers if the inciting tumor was diagnosed after the diagnosis of retinopathy.
NA: patient alive at the time of publication.