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Case Reports in Obstetrics and Gynecology
Volume 2012 (2012), Article ID 253152, 3 pages
Case Report

Steroid Cell Ovarian Neoplasm, Not Otherwise Specified: A Case Report and Review of the Literature

1Department of Obstetrics and Gynecology, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
2Division of Reproductive Medicine, Department of Obstetrics and Gynecology, John Peter Smith Hospital, Fort Worth, TX 76104, USA
3Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, John Peter Smith Hospital, Fort Worth, TX 76104, USA

Received 18 August 2012; Accepted 11 September 2012

Academic Editors: P. De Franciscis and E. Shalev

Copyright © 2012 Paul Singh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Steroid cell ovarian tumors, not otherwise specified, represent a unique cause of female virilization. Most commonly encountered in premenopausal women, these tumors can exist throughout a women’s lifetime, from before puberty until after menopause. Case. Steroid cell, not otherwise specified, was diagnosed in a 70-year-old female significant for hirsutism. The patient demonstrated elevated total testosterone levels with normal gonadotropins, DHEA, and DHEA-S levels. CT imaging revealed a right ovarian mass and subsequent laparoscopic right oophorectomy yielded clinical improvement promptly. Conclusion. Virilization in females can occur based on ovarian or adrenal pathology. In terms of ovarian-based female virilization, many tumors exist that may induce women to demonstrate masculine features, such as pure Sertoli, pure Leydig, Sertoli-Leydig combinations, and gynandroblastomas. Each of these tumor types possesses a unique histologic pattern that allows for pathologic identification after removal. A rare source of ovarian-based female virilization is steroid cell neoplasms, not otherwise specified, that do not demonstrate these specific histologic characteristics and thus represent a diagnosis of exclusion after other causes of ovarian-based female virilization have been ruled out.